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Ciencia e Innovación frente al Coronavirus >
Investigaciones
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Studies in biology and behavior of the virus
Funding COVID-19 Fund
| Project | Centre involved | Description |
|---|---|---|
| ngs analysis of the SARS-CoV-2 outbreak at Elche General Hospital | Foundation for the Promotion of Health and Biomedical Research of the Valencian Community (FISABIO) | The achievement of new genomic sequences of the coronavirus is the objective of this research that will carry out characterization studies of the virus to know its possible genetic variations and the virus-host interaction. The information obtained will serve to carry out epidemiological studies. |
| Funcional characterization of SARS-CoV-2-specific T and B cell long-lasting immunity in immunocompetent and immunosupressed patients developing SARS-CoV-2 infection (COV-Immunity) | Biomedical Research Institute of Bellvitge (IDIBELL) | He leads a study to improve the characterization of the virus, know the capacity for genetic and antigenic variation, deepen the virus-host interaction and manage the body's immune response to infection. |
| Interaction between SARS-CoV-2 and the human respiratory epithelium: sequestration of endocytosis pathways and exocytosis | University of Extremadura | He leads a project on the interaction between SARS-CoV-2 and the human respiratory epithelium. The objectives are to study how the virus enters the body through the epithelial cells of the respiratory tract and to analyze the action of the virus on epithelial cells of the respiratory system. |
| Study to dissect the molecular pathways that allow the interaction between the virus and the host | University of Oviedo | SARS-CoV-2. The objective is to deepen the biological knowledge of the virus and its interaction with the body to have more data that will allow us to find the best targets against which to direct possible new treatments. |
| SARS-CoV-2 Inhibition, Host Selection and Next-Move Prediction Through High-Performance Computing | IRB Barcelona (Institute of Biomedical Research) | He leads a project based on bioinformatics and computation to improve the understanding of how the virus uses the cellular receptor ACE2 to enter cells, with the aim of facilitating the knowledge of how the infection occurs and to estimate how it can evolve in coronavirus families. This information will serve to begin new drug search studies that inhibit the interaction between the virus and its host. |
| Decoy-ACE2: Use of catalytically inactivated soluble ACE2 as an anti-COVID-19 drug | Consortium Center for Biomedical Research in Red, M.P, (CIBER) | It coordinates research based on protein engineering and structural biology, which aims to inhibit the entry of coronavirus into cells by administering large amounts of soluble viral receptor (ACE2). This approach can be the basis for the development of new drugs. |
| Deciphering ACE2-mediated SARS-CoV-2 lung infection | Balearic Islands Health Research Institute (IDISBA) | It coordinates a study on the ACE2 receptor, the key to the entry of the coronavirus into the body, to identify how and where the infection begins. The genetic variants of the said receptor in the Spanish population will also be studied to know how this process of entry of the virus and its consequences can differ, something that may have implications for the development of new therapies. In addition, CRISPR/Cas9 will be used to study how the infection affects the epithelial organization. |
| Disruption of viral transport processes mediated by microtubules | Center for Biological Research Margarita Salas (CIB-CSIC) | It leads a project around the dependence of SARS-CoV-2 on microtubules for the development of infection; thus, microtubules can constitute an effective target to stop their replication. By visualizing the movement of microtubular transporters, their response to tiny concentrations of drugs can be evaluated, so the research will analyze the world’s largest library of anti-tubulin drugs. To do this, the project will carry out a screening search for drugs that inhibit this transport and study viral replication at tolerable doses. |
| VirionBreak: Dynamic calculation of the SARS-CoV-2 capsid for its destruction by resonance | University of A Coruña | The VirionBreak project will carry out a structural dynamic analysis of the capsid of the SARS-CoV-2 virus to obtain its frequencies and modes of vibration and to be able to determine the characteristics of a radio frequency emission that can cause its collapse and elimination. The resulting device could be used for immediate prophylactic purposes for the disinfection of inert material and contaminated biological waste. If it is determined that the vibration frequencies and energy needed to cause capsid destruction are harmless, this approach could also be applied for therapeutic purposes. |
| Structural analysis of SARS-CoV-2 membrane proteins for the design of new viral assembly inhibitors | Institute of Biomedicine of Valencia (IBV-CSIC) | Structural analysis of SARS-CoV-2 membrane proteins with the aim of designing new inhibitors of viral assembly. The research seeks to improve the knowledge of protein-protein interactions between structural viral proteins, a basic information to understand how coronaviruses are assembled and to be able to design therapeutic tools that prevent it. |
| Structural and Dynamic Characteristics of Intrinsically Disordered SARS-CoV-2 Virus Proteins | Rocasolan Chemical-Physical Institute (IQFR-CSIC) | Study of the structural and dynamic characteristics of a type of SARS-CoV-2 virus proteins called Intrinsically Disordered Proteins, which are essential for viral infections. The research seeks to characterize the partial structure and dynamics of three disordered proteins and three peptides of the coronavirus proteome, through magnetic resonance spectroscopy and molecular dynamics techniques. |
| Design and development of peptide inhibitors of SARS CoV2 virus entry for human use | Alberto Sols Biomedical Research Institute (CSIC-UAM) | Study to design and develop peptides that can inhibit the entry into the body of SARS-CoV-2. Through screening tools, research will look for new therapeutic compounds that prevent the development of the infection. |
CDTI funding
| Project | Centre involved | Description |
|---|---|---|
| Treatment of respiratory infections caused by COVID-19 | PALO BIOFARMA S.L. | Discovery of new inhibitors of the ACE2 protein for the treatment of respiratory infections caused by coronavirus, such as COVID-19. |
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