The Network of Nuclear Magnetic Resonance Laboratories of Biomolecules (R-LRB) is an ICTS distributed in the area of health sciences, dedicated to Nuclear Magnetic Resonance (NMR) spectroscopy. The R-LRB offers coordinated open access to improve national competitiveness in the area of biomolecular MRI, through specific instrumentation and a solid know-how of its researchers and technical specialists.
NMR is the most versatile technique for the study of molecules at atomic resolution, and offers unique capabilities for the characterization of biomolecules. Currently, the network supports research developed in the following areas: characterization of intrinsically disordered proteins, rapid NMR methods, structural determination of proteins, peptides, nucleic acids and carbohydrates, studies of biomolecule dynamics, metabolomics and characterization of biomolecular interactions in the field of drug design.
The R-LRB is comprised of a network of high-field spectrometers, including three 800 MHz and three 600 MHz equipment, located in three laboratories:
MRI Laboratory of the University of Barcelona (LRB)
It is located in a space of 722 m2 in the modular building of the Barcelona Science Park, specially designed to house high-field NMR spectrometers. The LRB has been offering competitive access to its high-field instrumentation since 2000. His main area of expertise is focused on the study of dynamic biomolecular systems: characterization of intrinsically disordered proteins, and drug design, targeting targets that can be both globular and intrinsically disordered proteins.
It is located in the Rocasolan Institute of Physical Chemistry of the CSIC. It began its activity in 1964 when it acquired its first NMR spectrometer and has continued uninterrupted until today. It is equipped with advanced equipment in the field of structural biology. The LMR maintains a close relationship with the research groups of the CSIC and other nearby campuses and offers its experience for the implementation of experiments to non-expert users, collaborating in the design of strategies or in the interpretation of data.
It is located in the Center for Cooperative Research in Biosciences - CIC bioGUNE, in the Technological Park of Biscay. It has a large number of probes that allow a wide range of experiments, including the interaction between biomolecule ligands, the screening of compounds for the pharmaceutical industry and the analysis of alternative nuclei such as fluoride or selenium. The equipment is adapted to work in conditions of high salinity. The facilities have recently been improved with the creation of a laboratory dedicated to the metabolic analysis of biological samples.
