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Ciencia e Innovación frente al Coronavirus >
Investigaciones
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Studies in immunity
Funding COVID-19 Fund
| Project | Centre involved | Description |
|---|---|---|
| Development of vehicles for the generation of immunity through the incorporation of viral proteins into microspheres | University of Santiago de Compostela | Analysis of the use of a technology that seeks to trigger an immune response to the virus as effectively as possible. The project is led by the University of Santiago de Compostela and is based on the use of microspheres in which different SARS-CoV-2 proteins (specifically, domains such as S1, M or N) have been inserted to generate an immune response against the virus in the patient. The research, which will be carried out first with animal models, is a bet for diversification in the search for vaccines against the COVID-19 disease. |
| Search for immunological, prognostic and therapeutic markers in patients with COVID-19 | Fundación Instituto de Investigación Marqués de Valdecilla (IDIVAL) | It seeks immunological, prognostic and therapeutic markers in patients affected by COVID-19, analyzing innate and acquired immunity as a starting point to have more data that facilitate the search for possible vaccine developments. |
| Immunosenescence as a risk factor for SARS-CoV-2 infection | Biodonostia Health Research Institute | It analyzes how the ‘aging’ of immune systems, a process known as immunosenescence, can be a risk factor for SARS-CoV-2 infection. The research aims to improve the search for prognostic factors for the disease. |
| Impact of monoclonal B lymphocytosis and the state of the immune system on the development and evolution of COVID-19 infection in adults | Biomedical Research Institute of Salamanca (IBSAL) | It analyzes the relationship of ‘aged’ immune systems with COVID-19, studying the impact of monoclonal B lymphocytosis and the state of the immune system on the development and evolution of infection in adults. |
| Immunological and virological factors in COVID-19 and their correlation with the evolution to severe forms of the disease | Balearic Islands Health Research Institute (IDISBA) | Study of the immunological and virological factors in COVID-19, and its correlation with the evolution to severe forms of the disease. It will allow to select patients who are candidates for greater surveillance and to be treated with various therapeutic options; identify targets for the use of immunomodulatory drugs, and avoid or shorten hospital admissions in cases in which a favorable evolution of patients can be predicted. |
| Analysis of soluble markers of immune activation and NK and CD8 T cell populations in patients with SARS-CoV-2 infection | Institute of Health Research Aragon (IISA) | Research on the development and magnitude of the immune response during COVID-19 disease, with the aim of generating knowledge about the populations of immune cells responsible for the control of the infection. To do this, we seek to identify prognostic biomarkers to find possible personalized treatments. |
| Study on the evolution of the appearance and maintenance of memory T lymphocytes | Foundation of the Mar Institute for Biomedical Research (FIMIB) | He leads a new project that will influence the evaluation of the specific immune response against SARS-CoV-2. The study will analyze the characteristics of the immune response, regardless of clinical manifestations, and the evolution of infection in patients with chronic inflammatory diseases. Another objective is to assess whether immunosuppressive treatments may have any positive or negative impact on the course of infection and on the development of immune memory. |
| Exploration of the cytokine profile and its predictive capacity of gravity | HM Hospitals Research Foundation | Coordinates a study to identify cytokine profiles capable of predicting the development of respiratory distress associated with SARS-CoV-2 infection. The analysis will focus on proteins already being worked on by companies developing diagnostic kits, to ensure that markers found on immune response can be quickly made available in healthcare facilities. A second phase of the project will focus on the development of more accurate and patentable diagnostic technologies. |
| Exploiting protective immune responses to COVID-19 to unravel mechanisms associated with favorable clinical outcomes (Estudio 'Protective') | Foundation for Biomedical Research of the Ramón y Cajal Hospital (FIBio-HRC) | He coordinates the Protective study, which seeks to investigate the most beneficial immune reactions against SARS-CoV-2 to unravel biological mechanisms associated with a better prognosis in the development of COVID-19. Patients of all ages, including children, will be studied to better understand the variability and severity of COVID-19 according to different risk factors. |
| COVID-19, immune risk profile | Vall d'Hebron Research Institute | Coordinates a study on the various immune risk profiles in COVID-19. The main objective is to generate algorithms and indices to stratify patients according to their immune and virological risk profile, information that can facilitate the analysis of clinical trials with immunomodulators. |
| COVID-19, immune risk profile (attached to the project presented by the VHIR IP R Pujol-Borrell) | Biomedical Research Institute of Bellvitge (IDIBELL) | Coordinates a project to improve the knowledge of the immune risk profile in COVID-19. The study is based on the generation of algorithms to stratify patients by the immune risk profile, analyze clinical trials with immunomodular drugs and support the best therapeutic strategies. |
| Identification and characterization of the protective T immune response against SARS-CoV-2: Successfully guiding the design of vaccines | IrsiCaixa AIDS Research Institute | He leads a study to identify and characterize more concretely and accurately the protective immune response against SARS-CoV-2, a knowledge that can guide the design of possible vaccines; the ultimate goal is to achieve immunity and prolonged population protection against SARS-CoV-2 through vaccination. |
| Regulation of macrophage extravasation by α2 adrenergic agonists in the STC associated with COVID-19 | Fundación Canaria Institute of Health Research of the Canary Islands (FIISC) | He leads research to study alpha-2 adrenergic receptor agonists and prevent the accumulation of neutrophils in an inflammatory focus. The objective of this approach is to achieve an anti-inflammatory effect that can help combat the cytokine storm that is generated in severe phases of COVID-19, controlling this exaggerated and uncontrolled reaction of the immune system. |
| Levels of naïve T lymphocytes as a predictive factor of the efficacy of the immune response against SARS-CoV-2 and its potential vaccines | Foundation for Bio-Health Research and Innovation in Asturias (FINBA) | He leads research to study the levels of naïve T lymphocytes as a predictive factor of the effectiveness of the immune response against SARS-CoV-2 and its potential vaccines. The objective is to define the lymphocyte profile that characterizes patients with different development and severity profiles of COVID-19, to predict the greater or lesser risk of complications, analyzing the profiles that could best benefit from a possible vaccine. |
| Congenital errors of immunity and predisposition to infection by SARS-Cov-2 and to the severity of COVID-19. Coordinated international action of complete exomic sequencing | University Hospital La Paz (Foundation for Biomedical Research) | He coordinates a project focused on congenital errors of immunity and predisposition to SARS-CoV-2 infection and the severity of COVID-19. Thanks to a work of complete exomic sequencing in patients under 50 years of age from all over Spain with no known comorbidities or risk factors, researchers hope to improve genetic knowledge around the development of the disease. The Health Research Institute of the Canary Islands has received funding, for this same project, which will coordinate with researchers from the Hospital La Paz to advance genomic research on the predisposition to SARS-CoV-2 infection and development of COVID-19. |
| Congenital errors of immunity and predisposition to infection by SARS-Cov-2 and to the severity of COVID-19. Coordinated international action of complete exomic sequencing | Fundación Canaria Institute of Health Research of the Canary Islands (FIISC) | It participates in this project focused on the inborn errors of immunity and predisposition to SARS-CoV-2 infection and the severity of COVID-19. Thanks to a work of complete exomic sequencing in patients under 50 years of age from all over Spain with no known comorbidities or risk factors, researchers hope to improve genetic knowledge around the development of the disease. The Health Research Institute of the Canary Islands has received funding, for this same project, which will coordinate with researchers from the Hospital La Paz to advance genomic research on the predisposition to SARS-CoV-2 infection and development of COVID-19. |
| COVID-19, immune risk profile (attached to the project presented by the VHIR IP R Pujol-Borrell) | Germans Trias i Pujol Research Institute | Research on immunological risk profiles, attached to another project presented by the Research Institute of the Vall D’Hebron Hospital. The objective is to generate algorithms to stratify patients according to their immune risk profile and apply this knowledge to the analysis of clinical trials with immunomodular drugs. |
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